Related Experiment Video
Updated: Jul 27, 2025
09:44
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
3.0K
Obesity and female infertility
1College of Medicine, Mohammed Bin Rashid University of Medicine, and Health Sciences, Building 14, Al Razi St., Umm Hurair 2, Dubai Healthcare City, P.O. Box 505055, Dubai, United Arab Emirates.
Summary
Obesity negatively impacts fertility, but evidence for lifestyle or drug interventions improving live birth rates in obese women is limited. More research is needed on effective fertility treatments for obesity.
Area of Science:
- Reproductive Endocrinology
- Public Health
- Obesity Medicine
Background:
- Infertility affects global health and well-being.
- The link between obesity and infertility is established but mechanisms and optimal management remain unclear.
Purpose of the Study:
- To review recent literature on the association between maternal weight and live birth rates.
- To evaluate the effectiveness of interventions for obese women experiencing infertility.
Main Methods:
- Literature review focusing on studies assessing live birth rates.
- Analysis of correlations between preconception maternal weight and fertility outcomes.
Main Results:
- Over half of reviewed studies indicated an inverse correlation between preconception maternal weight and live birth rates.
- Insufficient evidence was found to support the efficacy of preconception lifestyle or pharmacological interventions in improving live birth rates for obese women.
Conclusions:
- Clinical practice may require flexible body mass index targets for fertility treatment access.
- Further large-scale clinical trials are necessary for new pharmacological treatments and bariatric surgery in managing obesity-related infertility.
Related Concept Videos
01:28Infertility in Females
355
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
355
01:24Obesity
552
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
552
02:07Oogenesis
63.9K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.9K
01:23Infertility in Males
299
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
299
01:24Disorders of the Female Reproductive System
421
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
421
01:28Menopause
209
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
209