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Updated: Jul 27, 2025

Anaerobic Growth and Maintenance of Mammalian Cell Lines
Published on: July 21, 2018
Metabolism: How a eukaryote adapted to life without respiration
Lloyd Cool1, Samuel Hanon1, Kevin J Verstrepen1
1VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium.
Abstract:
A new study finds that Schizosaccharomyces japonicus, a eukaryote that lost the ability to respire, modified its central carbon metabolism to maintain efficient ATP production, cofactor regeneration, and amino-acid production. This remarkable metabolic flexibility opens new avenues towards applications.
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