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Talaromyces rugulosus ventriculitis diagnosed by nanopore amplicon sequencing, 2022
Yoonkyung Lee1, Narae Kim2, Seungae Kim2
1Department of Neurology, Laboratory for Neurotherapeutics, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, 03080, South Korea; Department of Neurology, Dong-A University Hospital, Busan, 49315, South Korea.
Abstract:
Ventriculitis has serious complications and a high mortality rate, so it is important to early identification of the pathogen for appropriate treatment. We report case of ventriculitis caused by Talaromyces rugulosus, a rare pathogen, in South Korea. Affected patient was immunocompromised. Repeated cerebrospinal fluid culture tests were negative, but the pathogen was identified by fungal internal transcribed spacer amplicon nanopore sequencing. The pathogen was detected outside the endemic area of talaromycosis.
