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Transient depersonalisation/derealisation syndrome from tramadol

Suthimon Thumtecho1, Sorawit Wainipitapong2, Polpat Tantakitti3

  • 1Division of Toxicology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand suthimont@gmail.com.

BMJ Case Reports
|June 6, 2023
PubMed
Summary

Tramadol may cause transient depersonalisation/derealisation (DD) syndrome, especially when combined with CYP2D6 inhibitors like etoricoxib. This drug interaction can increase tramadol concentration, leading to these dissociative symptoms.

Keywords:
Drug interactionsPsychiatryToxicology

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