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Updated: Jul 27, 2025

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Adipose tissue is associated with kidney function parameters.

Katharina Mueller-Peltzer¹, Ricarda von Krüchten², Roberto Lorbeer³

¹Department of Diagnostic and Interventional Radiology, Faculty of Medicine Freiburg, Medical Center, Universitätsklinikum Freiburg, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany. katharina.mueller-peltzer@uniklinik-freiburg.de.

Scientific Reports

|June 6, 2023

Summary

This summary is machine-generated.

Visceral adipose tissue (VAT) is linked to reduced kidney function, specifically with higher cystatin C levels and lower estimated glomerular filtration rate (e-GFRcys) in individuals without cardio-renal disease.

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Area of Science:

Nephrology
Endocrinology
Radiology

Background:

Obesity is characterized by excess adipose tissue accumulation.
The direct impact of adipose tissue on kidney function remains unclear.
Understanding this relationship is crucial for preventing kidney disease.

Purpose of the Study:

To investigate the association between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with kidney function markers.
To examine the relationship between VAT and SAT with serum creatinine, cystatin C, and estimated glomerular filtration rate (e-GFR) in individuals without cardio-renal diseases.

Main Methods:

A population-based study (KORA-MRI) involving 377 subjects.
Whole-body 3T-MRI for quantifying VAT and SAT.
Serum creatinine and cystatin C measurements, with e-GFR calculated using various formulas (e-GFRcrea, e-GFRcys, e-GFRcc).
Linear regression analysis adjusted for risk factors.

Main Results:

Visceral adipose tissue (VAT) showed a significant inverse association with e-GFRcys (p < 0.001) and a positive association with serum cystatin C (p < 0.001).
No significant associations were found between total adipose tissue (TAT), SAT, and serum creatinine, urine microalbumin, or e-GFRcrea.
Results were confirmed in stratified analyses for individuals with a BMI > 30.

Conclusions:

Visceral adipose tissue (VAT) is directly involved in altered cystatin C metabolism.
Increased VAT is associated with decreased kidney function, as indicated by cystatin C-based e-GFR.
These findings highlight the detrimental role of visceral fat accumulation on renal health.