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Ning Xu1, Haifeng Lin2, Qiuling Du1

  • 1Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China. wangpeilong@caas.cn.

Lab on a Chip
|June 7, 2023
PubMed
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A new filter-chip-solid phase extraction-mass spectrometry (SPE-MS) system efficiently removes persistent per- and polyfluoroalkyl substances (PFASs). This platform also tracks their metabolism in human cells, aiding in developing antidotes and toxicology assays.

Area of Science:

  • Environmental Science
  • Materials Science
  • Toxicology

Background:

  • Over 9000 types of per- and polyfluoroalkyl substances (PFASs) are persistent, bioaccumulative, and toxic, posing risks to human health.
  • Metal-organic frameworks (MOFs) show promise for PFAS adsorption, but their development is challenged by PFAS structural diversity and variable pharmacologic actions.

Purpose of the Study:

  • To develop an in situ platform for high-throughput identification of efficient MOF sorbents for PFAS adsorption and metabolism monitoring.
  • To demonstrate the utility of the filter-chip-solid phase extraction-mass spectrometry (SPE-MS) system for tracking pollutant detoxification and biotransformation.

Main Methods:

  • Screening of MOF materials for per- and polyfluoroalkyl substances (PFASs) adsorption using a filter-chip-SPE-MS system.

Related Experiment Videos

  • Utilizing microfluidic chips to culture human cells (HepG2, HCT116, HKC, HUVEC) for metabolism studies.
  • Real-time tracking of cell metabolites using SPE-MS to assess fluorotelomer alcohol (FTOH) metabolism.

    • Main Results:

    • BUT-16 was identified as an efficient MOF sorbent for fluorotelomer alcohol (FTOH) adsorption, achieving 100% removal in 1 minute via hydrogen bonding with Zr6 clusters.
    • The filter-chip-SPE-MS system successfully monitored FTOH metabolism in various human cell lines.
    • The system demonstrated versatility in real-time monitoring of pollutant detoxification and biotransformation.

    Conclusions:

    • The developed filter-chip-SPE-MS system is a robust platform for real-time monitoring of pollutant detoxification, biotransformation, and metabolism.
    • This platform facilitates the development of pollutant antidotes and advances toxicology assays.
    • The study highlights the potential of MOFs, like BUT-16, in addressing the challenge of persistent organic pollutant removal.