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Duong Quang Huan1, Nguyen Quang Hop1, Ninh The Son2

  • 1Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), Nguyen Van Linh, Xuanhoa, Phucyen, Vinhphuc, Vietnam.

Current Pharmaceutical Biotechnology
|June 7, 2023
PubMed
Summary
This summary is machine-generated.

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This review highlights the rich phytochemical diversity of Wikstroemia plants, identifying over 290 metabolites. Pharmacological studies confirm their traditional uses, showing anticancer, anti-inflammatory, and neuroprotective effects.

Area of Science:

  • Ethnobotany
  • Natural Product Chemistry
  • Pharmacology

Background:

  • Wikstroemia, a genus in the Thymelaeaceae family, comprises valuable medicinal plants with a long history of traditional use.
  • Specific species like W. indica are traditionally employed for treating various ailments including cancer, arthritis, and syphilis.
  • A comprehensive review of bioactive compounds and pharmacological effects within the Wikstroemia genus is currently lacking.

Purpose of the Study:

  • To systematically review phytochemical investigations of Wikstroemia plant extracts.
  • To summarize the pharmacological effects of compounds isolated from Wikstroemia species.
  • To consolidate existing knowledge on the medicinal potential of the Wikstroemia genus.

Main Methods:

  • Extensive literature search conducted across major scientific databases (Web of Science, Google Scholar, PubMed, Sci-Finder).
Keywords:
ThymelaeaceaeWikstroemiaanticancer.pharmacologyphytochemistryterpenoids

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  • Data retrieval focused on phytochemical constituents and documented pharmacological activities of Wikstroemia plants.
  • Systematic compilation and analysis of identified metabolites and their associated biological effects.

    • Main Results:

    • Over 290 structurally diverse metabolites have been identified from the Wikstroemia genus.
    • Key compound classes include terpenoids, lignans, flavonoids, coumarins, and anthraquinones.
    • Wikstroemia extracts and isolates exhibit a broad spectrum of pharmacological activities, including anticancer, anti-inflammatory, anti-aging, antiviral, antimicrobial, antimalarial, neuroprotective, and hepatoprotective effects.

    Conclusions:

    • Wikstroemia is a pharmacologically promising genus with significant phytochemical diversity, validating many traditional medicinal applications.
    • Modern research supports the ethnobotanical uses of Wikstroemia, demonstrating diverse bioactivities.
    • Further investigation into the precise mechanisms of action for these compounds is warranted, with a focus on under-researched metabolite classes beyond terpenoids, lignans, flavonoids, and coumarins.