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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

157
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
157
Drug Delivery: Overview01:16

Drug Delivery: Overview

329
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
329
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

330
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
330
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

236
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
236
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

903
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
903
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

645
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
645

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Related Experiment Video

Updated: Jul 27, 2025

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Transformative Materials for Interfacial Drug Delivery.

Prachi Desai1, Anshuman Dasgupta1, Alexandros Marios Sofias1,2

  • 1Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074, Aachen, Germany.

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|June 7, 2023
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Summary
This summary is machine-generated.

Drug delivery systems (DDS) improve drug efficacy and reduce side effects by controlling drug release. This review highlights how DDS overcome biological barriers and modulate host-material interactions for better disease treatment.

Keywords:
biomaterialsbiomedical engineeringdrug deliverydrug targetingnanomedicines

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Drug delivery systems (DDS) are crucial for optimizing therapeutic outcomes.
  • DDS aim to enhance drug efficacy while minimizing toxic side effects.
  • They are vital for overcoming biological barriers and managing host-material interactions.

Purpose of the Study:

  • To provide an overview of biological barriers and host-material interfaces for DDS.
  • To highlight material engineering advances in DDS.
  • To exemplify how DDS can improve disease treatment.

Main Methods:

  • Literature review of biological barriers and host-material interfaces.
  • Analysis of material engineering strategies for DDS.
  • Discussion of DDS applications in oral, intravenous, and local administration.

Main Results:

  • DDS are engineered to control drug release temporally and spatially.
  • They effectively address biological barriers across various administration routes.
  • Material engineering advances offer new possibilities for DDS design.

Conclusions:

  • DDS play a significant role in balancing therapeutic efficacy and toxicity.
  • Understanding biological barriers and host-material interfaces is key for DDS development.
  • Future DDS innovations hold promise for advancing disease treatment.