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Updated: Jul 27, 2025
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
Published on: May 24, 2019
Integrated separation and detection of exosomes
Lingfei Han1,2, Chengcheng Zhu1, Zheng Tan1
1College of Chemistry and Materials Science and Analytical & Testing Center, Nanjing Normal University, Nanjing 210023, China. wangchen@njnu.edu.cn.
Abstract:
A label-free magnetic surface enhanced Raman scattering (SERS) platform was constructed, which was composed of superparamagnetic Fe3O4 nanoparticles as cores for separation and Au layers as shells for label-free SERS detection. Our method could effectively distinguish exosomes from different cell sources for cancer diagnosis and showed high sensitivity and specificity within a 95% confidence interval. As a low-cost and efficient exosome analysis method, the designed integrated platform for separation and detection has promising applicability in clinical diagnostics.
