Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Plasma Glycoprotein Milieu in the Hemato-Oncological Patient Inhibits Platelet Function.

Biomolecules·2026
Same author

Survey of the human proteostasis network: the ubiquitin-proteasome system.

bioRxiv : the preprint server for biology·2026
Same author

"When I'm 64": functional shift of aging platelets.

Blood·2025
Same author

Treatment of Immune Thrombocytopenia: Contextualization from a Historical Perspective.

Hematology reports·2024
Same author

Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective.

Hematology reports·2024
Same author

Applicability of the Thrombin Generation Test to Evaluate the Hemostatic Status of Hemophilia A Patients in Daily Clinical Practice.

Journal of clinical medicine·2022

Related Experiment Video

Updated: Jul 27, 2025

Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

22.4K

Proteomics-wise, how similar are mouse and human platelets?

Patricia Martínez-Botía1,2, Patricia Villar1,2, Graciela Carbajo-Argüelles1,2

  • 1Platelet Research Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Platelets
|June 7, 2023
PubMed
Summary

Platelet proteomics offers a promising tool for diagnosing diseases and developing new treatments. Human and mouse platelets show conserved proteomes, supporting interspecies research for clinical applications.

Keywords:
Humaninterspeciesmegakaryocytesmouseplateletsproteomics

More Related Videos

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies
07:06

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

582
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.3K

Related Experiment Videos

Last Updated: Jul 27, 2025

Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

22.4K
Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies
07:06

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

582
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.3K

Area of Science:

  • Platelet biology and proteomics
  • Translational research in hematology

Background:

  • Platelets are key biosensors for health and disease.
  • Proteomics can identify disease-specific markers in platelets.
  • Alternative treatments are needed for pathologies involving thrombosis-bleeding imbalance.

Purpose of the Study:

  • Compare mouse and human platelet proteomes and secretomes.
  • Validate proteomics as a tool for platelet research across species.
  • Explore diagnostic and therapeutic applications of platelet proteomics.

Main Methods:

  • Comparative analysis of public database information on mouse and human platelet proteomes and secretomes.
  • Review of existing clinical and preclinical studies.

Main Results:

  • Human and mouse platelets exhibit highly conserved proteomes and secretomes, including protein abundance.
  • Growing body of evidence supports the use of proteomics in platelet research.
  • Improving data quality facilitates cross-study comparisons.

Conclusions:

  • Platelet proteomics is a valuable tool for identifying disease hallmarks and novel therapeutic targets.
  • Interspecies conservation supports the use of preclinical models in platelet research.
  • Future applications include diagnostics, prognostics, and improved therapies beyond hematopoiesis and transfusion medicine.