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Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea

Yaxin Zhu1, Shengming Wang1, Yingchao Yang1

  • 1Department of Otolaryngology Head and Neck Surgery and Center of Sleep Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Immunology
|June 7, 2023
PubMed

Insights

Severe adenoid hypertrophy in children shows more naive lymphocytes and fewer effector lymphocytes. This suggests abnormal lymphocyte changes may contribute to enlarged adenoids and obstructive sleep apnea.

Area of Science:

  • Pediatric immunology
  • Otolaryngology

Background:

  • Adenoid hypertrophy is a primary cause of pediatric obstructive sleep apnea.
  • Pathogenic infections and immune system disorders are linked to adenoid hypertrophy.
  • Lymphocyte subset abnormalities in adenoids are implicated but not fully understood.

Purpose of the Study:

  • To investigate lymphocyte subset patterns in children with varying degrees of adenoid hypertrophy.
  • To clarify the role of lymphocyte composition in adenoid enlargement.

Main Methods:

  • Utilized multicolor flow cytometry.
  • Analyzed lymphocyte subsets in children with mild to moderate (n=10) and severe (n=5) adenoid hypertrophy.

Main Results:

  • Severe adenoid hypertrophy demonstrated a significant increase in naive lymphocytes.
  • A significant decrease in effector lymphocytes was observed in severe cases.

Conclusions:

  • Abnormal lymphocyte differentiation or migration may be a factor in adenoid hypertrophy development.
  • Findings offer insights into the immunological mechanisms of adenoid hypertrophy.
Abstract

Keywords:
B cellsT cellsadenoid hypertrophymulticolor flow cytometryobstructive sleep apnea

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