Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

305
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
305
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
Autoimmune Disorders01:29

Autoimmune Disorders

529
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
529
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

612
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
612

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson's disease-relevant LRRK2-G2019S mutation.

iScience·2026
Same author

New insights in multiple sclerosis pathology.

Current opinion in neurology·2026
Same author

In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.

Science translational medicine·2026
Same author

Toward a Neuroimaging Consensus for the Work-up of Adult Genetic Leukoencephalopathies on Behalf of the White Matter Rounds Network: State of Practice.

AJNR. American journal of neuroradiology·2025
Same author

Development of a Human Preclinical Platform for the Identification of Neuroprotective Compounds.

The European journal of neuroscience·2025
Same author

White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy.

Neurobiology of disease·2025
Same journal

Alzheimer's disease in the <i>Plasticene</i> era: a clinicopathological update on the dual sequestration of amyloid and tau as hijacked innate immune responses.

Free neuropathology·2026
Same journal

An integrated multiscale imaging workflow to resolve intracellular co-pathology in human FFPE brain tissue.

Free neuropathology·2026
Same journal

Unclassifiable senile plaques and extensive cerebral amyloid angiopathy involving spinal and bridging vessels in autopsied patients with Down syndrome.

Free neuropathology·2026
Same journal

Brain extraction for fixed tissue banking: a technical report.

Free neuropathology·2026
Same journal

Forensic neuropathology: 2026 update.

Free neuropathology·2026
Same journal

Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain.

Free neuropathology·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.1K

Multiple sclerosis: 2023 update.

Tanja Kuhlmann1,2, Jack Antel2

  • 1Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.

Free Neuropathology
|June 7, 2023
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) research in 2022 focused on understanding disease progression independent of relapses and exploring new conditions like MOGAD. New insights aim to tackle the challenges in treating progressive MS and related CNS inflammatory disorders.

Keywords:
EBVMultiple sclerosisRemyelinationSlowly expanding lesionsSpatial transcriptomics

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.5K

Related Experiment Videos

Last Updated: Jul 27, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.1K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.5K

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) inflammatory and demyelinating diseases

Background:

  • Multiple sclerosis (MS) is a primary inflammatory demyelinating CNS disease.
  • Current therapies effectively manage relapses but not progressive MS.
  • Early disease progression independent of relapse activity is a significant challenge.

Purpose of the Study:

  • To review 2022 publications on MS.
  • To provide insights into MS susceptibility and disease progression.
  • To discuss emerging inflammatory/demyelinating CNS disorders like MOGAD.

Main Methods:

  • Review of scientific literature published in 2022.
  • Synthesis of findings related to MS pathogenesis and progression.
  • Analysis of recent developments in understanding MOGAD.

Main Results:

  • Progress in understanding MS relapse prevention through immunomodulatory therapies.
  • Identification of continuous disease progression independent of relapses, starting early in MS.
  • Characterization of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as a distinct entity.

Conclusions:

  • Developing therapies for progressive MS remains a critical challenge.
  • Understanding early disease mechanisms is key to halting progression.
  • Research in 2022 advanced the understanding of MS and related disorders like MOGAD.