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Updated: Jul 27, 2025

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
Published on: July 25, 2022
Sub-second pair distribution function using a broad bandwidth monochromator.
Nicolas P L Magnard1, Daniel R Sørensen2,3, Innokenty Kantor3,4
1Department of Chemistry and Nano-Science Center, University of Copenhagen, Copenhagen 2100, Denmark.
Broad energy bandwidth multilayer mirrors enable high-quality X-ray total scattering and pair distribution function analysis. This method allows for rapid, time-resolved studies of metal oxo clusters in solution.
Area of Science:
- Materials Science
- Chemistry
- Physics
Background:
- X-ray total scattering (TS) and pair distribution function (PDF) analysis are crucial for structural determination.
- Traditional methods often require high-quality, monochromatic X-ray beams, limiting experimental speed and flexibility.
Purpose of the Study:
- To demonstrate the efficacy of a broad energy bandwidth monochromator, specifically B4C/W multilayer mirrors (MLMs), for TS and PDF analysis.
- To evaluate the quality of PDFs obtained using MLMs compared to standard methods.
- To investigate the impact of time resolution and concentration on PDF quality for metal oxo clusters.
Main Methods:
- Utilized a B4C/W multilayer mirror (MLM) system as a broad energy bandwidth monochromator.
- Performed X-ray total scattering (TS) measurements on powder samples and aqueous solutions of metal oxo clusters.
- Analyzed data using pair distribution function (PDF) analysis.
- Compared MLM-derived PDFs with those from a standard Si(111) double-crystal monochromator.
Main Results:
- MLM-based measurements yielded high-quality PDFs suitable for structure refinement.
- PDFs obtained with MLMs were comparable to those from conventional Si(111) monochromators.
- Time-resolved PDF analysis of heptamolybdate and tungsten α-Keggin clusters achieved resolutions down to 3 ms with minimal loss in data quality (Fourier ripples).
Conclusions:
- Broad energy bandwidth multilayer mirrors are effective for high-quality X-ray total scattering and PDF analysis.
- The MLM approach facilitates significantly faster time-resolved TS and PDF studies, particularly for dynamic systems like metal oxo clusters in solution.
- This technique offers a promising avenue for advanced structural investigations of transient phenomena.
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