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Dulaglutide (Trulicity)-Induced Acute Pancreatitis: A Case Report
Abu Baker Khan1, Aimal Shah2,3, Saad Ahmad4
1Internal Medicine, Ayub Teaching Hospital, Abbottabad, PAK.
Cureus
|June 7, 2023
Summary
This case report details a patient who developed acute pancreatitis after their dulaglutide (Trulicity) dosage was increased. It highlights potential adverse effects of this type 2 diabetes medication.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Type 2 diabetes mellitus (T2DM) management often involves glucagon-like peptide-1 (GLP-1) receptor agonists.
- Dulaglutide, a long-acting GLP-1 analog, enhances insulin secretion and reduces appetite.
- Standard dulaglutide dosage is 0.75 mg weekly, adjustable for glycemic control.
Observation:
- A 37-year-old male with T2DM presented with acute pancreatitis.
- The patient recently had his dulaglutide dose increased from 0.75 mg to 1.5 mg weekly.
- Symptoms of abdominal pain, nausea, and vomiting occurred after the last dulaglutide administration.
Findings:
- Elevated lipase levels (1508) and CT scan findings confirmed acute pancreatitis.
- Dulaglutide use is associated with mild pancreatic enzyme elevation, with few reported pancreatitis cases.
- This case suggests a potential link between increased dulaglutide dosage and acute pancreatitis.
Implications:
- Clinicians should be aware of the potential for dulaglutide-associated acute pancreatitis.
- Monitoring pancreatic enzyme levels in patients on dulaglutide, especially with dose adjustments, is crucial.
- Further research is needed to elucidate the risk of pancreatitis with GLP-1 receptor agonists.
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