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Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial.

Patricio Solis-Urra1,2,3, Cristina Molina-Hidalgo4,5, Yolanda García-Rivero2,6

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Resistance exercise may improve executive function in older adults, potentially delaying dementia risk. This study investigates exercise

Keywords:
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Area of Science:

  • Neurology
  • Gerontology
  • Exercise Science

Background:

  • Alzheimer's disease is a leading cause of dementia, with age-related executive function decline increasing risk.
  • Non-pharmaceutical interventions, like physical exercise, are explored for cognitive enhancement.
  • Executive function is crucial for daily activities and is impacted by aging.

Purpose of the Study:

  • To evaluate the effects of a 24-week resistance exercise program on executive function in cognitively normal older adults.
  • To explore secondary outcomes including brain structure, function, biomarkers, and psychosocial parameters.
  • To understand the mechanisms underlying exercise-induced cognitive benefits.

Main Methods:

  • A single-site, two-arm, single-blinded randomized controlled trial (RCT) involving 90 participants aged 65-80.
  • Participants were randomized to either a 24-week resistance exercise program or a wait-list control group.
  • Outcomes were assessed at baseline, 12 weeks, and 24 weeks, including cognitive tests, neuroimaging, and biomarker analysis.

Main Results:

  • The primary outcome is the change in executive function composite score.
  • Secondary outcomes include changes in brain structure, function, amyloid deposition, and molecular biomarkers.
  • Physical function, muscular strength, body composition, mental health, and psychosocial parameters will also be assessed.

Conclusions:

  • Resistance exercise is hypothesized to positively impact executive function and related brain changes.
  • The study aims to elucidate the molecular, structural, functional, and psychosocial mechanisms involved.
  • Findings could inform non-pharmaceutical strategies for maintaining cognitive health in aging populations.