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Exploring the Correlation Between
Xianhua Gu1, Honghong Shen2, Zheng Xiang3
1Department of Gynecology Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, People's Republic of China.
Pharmacogenomics and Personalized Medicine
|June 7, 2023
Summary
High GPR176 expression in gastric cancer (GC) correlates with poor prognosis and immune evasion. This orphan G protein-coupled receptor (GPCR) suppresses CD8+ T cells, indicating its role as a predictive biomarker for gastric cancer patients.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Gastrointestinal cancers, including gastric cancer (GC), are significantly influenced by G protein-coupled receptor 176 (GPR176).
- The precise role of GPR176 in modulating tumor immunity and patient outcomes in GC remains largely uncharacterized.
Purpose of the Study:
- To investigate the expression patterns of GPR176 in gastric cancer tissues and normal gastric mucosa.
- To evaluate the association between GPR176 expression, patient prognosis, and tumor immune infiltration in GC.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases for expression analysis.
- Performed immunohistochemistry and quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) for validation.
- Employed Kaplan-Meier, logistic regression, and Cox regression analyses to assess clinical correlations and prognostic value.
Main Results:
- Gastric cancer tissues exhibited significantly higher GPR176 expression compared to normal tissues.
- Elevated GPR176 expression was linked to a poorer 10-year overall survival (OS) in GC patients (p < 0.001).
- GPR176 expression negatively correlated with CD8+ T cell infiltration and was associated with increased immune evasion, as indicated by TIDE and IPS analyses.
Conclusions:
- GPR176 serves as a valuable predictive biomarker for adverse patient prognosis in gastric cancer.
- GPR176 contributes to immune evasion in GC by suppressing CD8+ T cell proliferation.
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