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Related Concept Videos

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Related Experiment Video

Updated: Jul 27, 2025

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
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Biomaterial-based gene therapy.

Yi Yu1, Yijun Gao1, Liming He2

  • 1Department of Stomatology The Second Xiangya Hospital Central South University Changsha China.

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|June 7, 2023
PubMed
Summary
This summary is machine-generated.

Biomaterials offer a safer alternative to viral vectors for gene therapy, improving nucleic acid delivery and stability. This review explores biomaterial-based systems for treating complex diseases like cancer and genetic disorders.

Keywords:
biomaterialgene therapynonviral vectorviral vector

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Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Gene Therapy

Background:

  • Gene therapy corrects defective genes for treating hereditary diseases, cancer, and immune disorders.
  • Traditional viral vectors face challenges like immunogenicity and infection risk.
  • Nucleic acids require efficient delivery systems to overcome degradation and cell membrane barriers.

Purpose of the Study:

  • To review recent advancements in gene therapy modalities.
  • To discuss nucleic acid delivery strategies, emphasizing biomaterial-based systems.
  • To summarize current applications of biomaterial-based gene therapy.

Main Methods:

  • Literature review of gene therapy developments.
  • Analysis of nucleic acid delivery challenges and solutions.
  • Focus on biomaterial applications in gene delivery.

Main Results:

  • Biomaterials enhance nucleic acid stability and intracellular delivery efficiency.
  • Biomaterial-based vectors mitigate risks associated with viral vectors.
  • These systems show promise for treating various complex diseases.

Conclusions:

  • Biomaterial-based gene delivery systems represent a significant advancement in therapeutic strategies.
  • They offer a safer and more effective approach compared to traditional viral vectors.
  • Further research and application of these systems are crucial for disease treatment.