Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

612
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
612
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

536
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
536
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

224
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
224
Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

886
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
886
Neuroplasticity01:01

Neuroplasticity

604
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
604

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lewy pathology largely absent in prefrontal cortices of Parkinson's disease patients undergoing deep brain stimulation.

NPJ Parkinson's disease·2026
Same author

Validity of the NINDS traumatic encephalopathy syndrome criteria for predicting chronic traumatic encephalopathy.

medRxiv : the preprint server for health sciences·2026
Same author

A new AI assisted approach aligns data standards and accelerates interoperability in biomedical research.

NPJ digital medicine·2026
Same authorSame journal

Brain extraction for fixed tissue banking: a technical report.

Free neuropathology·2026
Same author

Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy.

Journal of neuropathology and experimental neurology·2026
Same author

Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration.

Acta neuropathologica·2026
Same journal

Alzheimer's disease in the <i>Plasticene</i> era: a clinicopathological update on the dual sequestration of amyloid and tau as hijacked innate immune responses.

Free neuropathology·2026
Same journal

An integrated multiscale imaging workflow to resolve intracellular co-pathology in human FFPE brain tissue.

Free neuropathology·2026
Same journal

Unclassifiable senile plaques and extensive cerebral amyloid angiopathy involving spinal and bridging vessels in autopsied patients with Down syndrome.

Free neuropathology·2026
Same journal

Forensic neuropathology: 2026 update.

Free neuropathology·2026
Same journal

Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain.

Free neuropathology·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.0K

Neurodegeneration: 2021 update.

John F Crary1

  • 1Neuropathology Brain Bank & Research CoRE, Department of Pathology, Nash Family Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Free Neuropathology
|June 7, 2023
PubMed
Summary
This summary is machine-generated.

Key 2020 neuropathology research highlights include COVID-19's neurological links, advances in Alzheimer's disease biomarkers, and insights into tau and alpha-synuclein protein structures in neurodegenerative diseases.

Keywords:
Alzheimer diseaseChronic traumatic encephalopathyCryogenic electron microscopyNeurodegenerationNeuropathologyProteomicsTauopathyα-synucleinopathy

More Related Videos

Studying Pre-formed Fibril Induced &#945;-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

10.7K
High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

17.6K

Related Experiment Videos

Last Updated: Jul 27, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

10.0K
Studying Pre-formed Fibril Induced &#945;-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

10.7K
High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

17.6K

Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases
  • Molecular Biology

Background:

  • The year 2020 saw significant advancements in understanding neurodegenerative diseases.
  • Research trends evolved from transcriptomics to proteomics, focusing on glial contributions and protein modifications.
  • Emerging links between COVID-19 and neurological symptoms spurred new research directions.

Purpose of the Study:

  • To review impactful research topics and trends in experimental and diagnostic neuropathology for 2020.
  • To provide a balanced overview of key developments across various neurodegenerative conditions.
  • To highlight transformative studies in Alzheimer's disease, Huntington's disease, and chronic traumatic encephalopathy.

Main Methods:

  • Review of selected manuscripts and research trends from 2020.
  • Analysis of studies employing proteomics, cryo-electron microscopy, and sensitive biomarker assays.
  • Examination of molecular data related to protein aggregation, cellular stress responses, and glial cell function.

Main Results:

  • COVID-19's potential to trigger neurodegenerative changes is a significant emerging research area.
  • Proteomics revealed glial roles in Alzheimer's disease and tau protein modifications.
  • Advances in plasma biomarkers for Alzheimer's disease enable detection of abnormal tau in blood.
  • Cryo-electron microscopy provided near-atomic resolution of alpha-synuclein aggregates and tau inclusions.
  • Studies elucidated alpha-synuclein strains and cellular adaptation to endoplasmic reticulum stress in Huntington's disease.
  • The role of astrocytes in chronic traumatic encephalopathy gained prominence.

Conclusions:

  • 2020 research underscored the complexity of neurodegenerative diseases, with significant progress in molecular understanding and diagnostics.
  • The interplay between viral infections and neurodegeneration, particularly with COVID-19, is a critical future research avenue.
  • Technological advancements like cryo-electron microscopy and sensitive biomarker assays are revolutionizing neuropathology research.