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VEGF-A related SNPs: a cardiovascular context.

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Vascular Endothelial Growth Factor-A (VEGF-A) shows promise as a biomarker for cardiovascular disease (CVD) risk. Genetic variations (SNPs) influencing VEGF-A levels may predict CVD development and associated risk factors.

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VEGF-A eQTLscardiovascular diseasegenetic associationsingle nucleotide polymorphismvascular endothelial growth factor

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Area of Science:

  • Cardiovascular Science
  • Genetics
  • Biomarker Discovery

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Current CVD risk algorithms lack predictive biomarkers for early detection.
  • Vascular Endothelial Growth Factor-A (VEGF-A) is crucial for blood vessel formation and a potential CVD biomarker.

Purpose of the Study:

  • To review the VEGF family, focusing on VEGF-A.
  • To summarize single nucleotide polymorphisms (SNPs) affecting VEGF-A plasma levels.
  • To explore the association of VEGF-A SNPs with CVD and CVD risk factors.

Main Methods:

  • Literature review of the VEGF family and VEGF-A.
  • Analysis of studies reporting SNPs influencing VEGF-A levels.
  • Examination of research linking VEGF-A variants to CVD and risk factors.

Main Results:

  • VEGF-A plays a complex role in the cardiovascular system.
  • Specific SNPs have been associated with altered circulating VEGF-A levels.
  • These VEGF-A variants show links to CVD development and risk factor profiles.

Conclusions:

  • VEGF-A is a significant molecule in cardiovascular health.
  • Genetic variations in VEGF-A influence its circulating levels and CVD risk.
  • VEGF-A SNPs represent potential biomarkers for cardiovascular disease risk assessment.