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Updated: Jul 27, 2025
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
9.8K
VEGF-A related SNPs: a cardiovascular context.
J C Meza-Alvarado1, R A Page1, B Mallard1
1School of Health Sciences, Massey University, Wellington, New Zealand.
Frontiers in Cardiovascular Medicine
|June 8, 2023
Summary
Vascular Endothelial Growth Factor-A (VEGF-A) shows promise as a biomarker for cardiovascular disease (CVD) risk. Genetic variations (SNPs) influencing VEGF-A levels may predict CVD development and associated risk factors.
Area of Science:
- Cardiovascular Science
- Genetics
- Biomarker Discovery
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Current CVD risk algorithms lack predictive biomarkers for early detection.
- Vascular Endothelial Growth Factor-A (VEGF-A) is crucial for blood vessel formation and a potential CVD biomarker.
Purpose of the Study:
- To review the VEGF family, focusing on VEGF-A.
- To summarize single nucleotide polymorphisms (SNPs) affecting VEGF-A plasma levels.
- To explore the association of VEGF-A SNPs with CVD and CVD risk factors.
Main Methods:
- Literature review of the VEGF family and VEGF-A.
- Analysis of studies reporting SNPs influencing VEGF-A levels.
- Examination of research linking VEGF-A variants to CVD and risk factors.
Main Results:
- VEGF-A plays a complex role in the cardiovascular system.
- Specific SNPs have been associated with altered circulating VEGF-A levels.
- These VEGF-A variants show links to CVD development and risk factor profiles.
Conclusions:
- VEGF-A is a significant molecule in cardiovascular health.
- Genetic variations in VEGF-A influence its circulating levels and CVD risk.
- VEGF-A SNPs represent potential biomarkers for cardiovascular disease risk assessment.
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