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Potential pitfalls in reporting non-neoplastic gastrointestinal mucosal biopsies
Mohammad Al-Qudah1,2, Khaled Murshed3, Husam K Haddad4
1Department of Microbiology and Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan. m.alqudah12@hu.edu.jo.
Histology and Histopathology
|June 8, 2023
Summary
Gastrointestinal tract (GIT) biopsies present diagnostic challenges due to variable histology and injury responses. This review highlights common pathological pitfalls in GIT biopsies to improve diagnostic accuracy for pathologists.
Area of Science:
- Gastroenterology
- Pathology
- Histopathology
Background:
- Biopsies from the gastrointestinal tract (GIT) are a substantial part of routine pathology workload.
- Organ-specific histology and diverse responses to injury in the GIT can lead to diagnostic challenges.
- Morphological variations in GIT biopsies may result in misdiagnosis.
Purpose of the Study:
- To review pathological conditions in the GIT that commonly lead to diagnostic pitfalls.
- To enhance awareness among pathologists and trainees about these challenging conditions.
- To offer a practical strategy for accurate diagnosis of GIT biopsies.
Main Methods:
- Literature review of pathological conditions in the gastrointestinal tract.
- Analysis of morphological changes causing diagnostic pitfalls.
- Synthesis of information to provide a pragmatic diagnostic approach.
Main Results:
- Identification of key pathological entities and patterns causing diagnostic errors in GIT biopsies.
- Elucidation of how variable histology and injury responses contribute to pitfalls.
- Compilation of common diagnostic challenges encountered in GIT pathology.
Conclusions:
- Awareness of specific pathological conditions is crucial for accurate GIT biopsy diagnosis.
- Understanding organ-specific responses to injury aids in avoiding diagnostic pitfalls.
- A pragmatic approach can improve diagnostic confidence and accuracy in gastrointestinal pathology.
