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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Focal Crescentic Pauci-Immune Glomerulonephritis in Systemic Lupus Erythematosus: A Case Report
Abdelaziz M Abusal1, Mohamed Ali2, Khaled Murshed3
1Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
Introduction:
We report a rare case of class III lupus nephritis presenting as crescentic pauci-immune glomerulonephritis - an unusual biopsy finding not captured in the current International Society of Nephrology/Renal Pathology Society classification, highlighting a diagnostic and therapeutic challenge.
Case Presentation:
A 24-year-old woman with systemic lupus erythematosus presented with preserved renal function, microscopic hematuria, nephritic-range proteinuria, elevated anti-dsDNA levels, negative antineutrophil cytoplasmic antibody serologies, and a kidney biopsy demonstrating focal crescentic pauci-immune glomerulonephritis with mesangial, subendothelial, and subepithelial electron-dense deposits, consistent with a rare histopathologic variant of class III LN.
Conclusion:
This case underscores the importance of kidney biopsy in atypical lupus presentations as histopathological findings may not always align with serological or clinical features, and can significantly influence diagnosis, prognosis, and management.
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