Impact of risk-reducing salpingo-oophorectomy on lipid determinants, HbA1c and CRP
R F M Vermeulen1,2, J L van Altena3, K N Gaarenstroom4
1Department of Gynecology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Insights
Risk-reducing salpingo-oophorectomy (RRSO) in premenopausal women led to significant increases in HDL-cholesterol and HbA1c, but no cardiovascular risk worsening. Postmenopausal women showed no significant changes after RRSO.
Area of Science:
- Oncology
- Endocrinology
- Cardiovascular Health
Background:
- BRCA1/2 mutation carriers are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) before age 45.
- The impact of RRSO on metabolic and inflammatory markers requires further investigation.
Purpose of the Study:
- To evaluate the effects of RRSO on lipid profiles, hemoglobin A1c (HbA1c), and C-reactive protein (CRP).
- To compare these changes between premenopausal and postmenopausal women.
Main Methods:
- 142 high-risk women (92 premenopausal, 50 postmenopausal) were studied.
- Serum lipids (LDL-C, HDL-C, total cholesterol, triglycerides), HbA1c, and CRP were measured before and at 6 weeks and 7 months post-RRSO.
- Hot flushes were also assessed.
Main Results:
- Premenopausal women showed significant increases in HDL-cholesterol, cholesterol ratio, and HbA1c within normal ranges.
- Hot flushes increased significantly in premenopausal women post-RRSO.
- Postmenopausal women experienced no significant changes; however, at 7 months, premenopausal women had lower LDL-C, triglycerides, HbA1c, and CRP compared to postmenopausal women, with higher HDL.
Conclusions:
- RRSO alters lipid profiles and HbA1c in premenopausal women, but these changes remain within reference ranges.
- No significant metabolic or inflammatory changes were observed in postmenopausal women.
- RRSO does not appear to increase cardiovascular risk within the first 7 months.
Objective:
Risk-reducing salpingo-oophorectomy (RRSO) is advised before 40-45 years of age for BRCA1/2 mutation carriers. This study describes the effect of RRSO on lipid determinants, hemoglobin A1c (HbA1c) and C-reactive protein (CRP).
Methods:
A total of 142 women with increased risk of ovarian cancer were included, 92 premenopausal and 50 postmenopausal. Serum levels of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and total cholesterol, triglycerides, HbA1c and CRP were determined at three points in time: before (T0) and 6 weeks (T1) and 7 months (T2) following RRSO. The Hot Flush Rating Scale was administered at the same time points.
Results:
In premenopausal women, levels of HDL-cholesterol, the cholesterol ratio and HBA1c increased significantly over time, although still staying within the reference range. In this group, hot flushes increased over time (p < 0.001). In postmenopausal women, no significant changes were observed following RRSO. At T2, serum LDL-cholesterol, triglycerides, HbA1c and CRP were significantly lower in premenopausal women compared to postmenopausal women, whereas HDL was increased.
Conclusions:
Seven months after RRSO, the lipid profile in premenopausal women had changed, although still staying within the reference range. For postmenopausal women, we did not observe any significant changes. Our results do not suggest a worsening of cardiovascular risk within 7 months of RRSO.
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