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A CAPTIVATEing Analysis for Higher-Risk CLL

Kerry A Rogers

    Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
    |June 8, 2023
    PubMed

    Abstract:

    In an exploratory analysis of the phase II CAPTIVATE study, previously untreated patients with chronic lymphocytic leukemia with a higher-risk feature of immune globulin heavy chain variable (IGHV) unmutated status, del(17p), and/or TP53 mutation had similar efficacy and safety outcomes compared with patients without a higher-risk feature when treated with fixed-duration ibrutinib and venetoclax. See related article by Allan et al., p. 2593.

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