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Estradiol Induces Neutrophil Expansion to Promote TSC-Null Tumor Progression

Diana C Marquez-Garban1, Mario Morales Martinez1, Richard J Pietras1,2

  • 1Department of Medicine, Division of Hematology-Oncology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA.

Endocrinology
|June 8, 2023
PubMed
Abstract

No abstract available in PubMed .

Keywords:
estrogenslymphangioleiomyomatosismyeloid derived suppressor cellsmyelopoiesisneutrophilstumor microenvironment

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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