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[Therapeutic advances in HER2+ breast cancer]

Marie Alexandre1, William Jacot2

  • 1Département d'oncologie médicale, Institut du cancer de Montpellier, Montpellier, France. Faculté de médecine de Montpellier-Nîmes, université de Montpellier, Montpellier, France.

La Revue Du Praticien
|June 8, 2023
PubMed

Insights

Advances in HER2-positive breast cancer treatment, including monoclonal antibodies and antibody drug conjugates (ADCs), have significantly improved patient outcomes. These targeted therapies are revolutionizing care for both localized and metastatic HER2+ breast cancer.

Area of Science:

  • Oncology
  • Medical Science

Context:

  • HER2-positive breast cancer represents 15-20% of the 58,000 new cases in France (2018).
  • HER2-targeted therapies have fundamentally changed the treatment landscape for these tumors.

Purpose:

  • To review the therapeutic advances in HER2-positive breast cancer.
  • To highlight the evolution of treatment strategies from monoclonal antibodies to antibody drug conjugates.

Summary:

  • Introduction of monoclonal antibodies (trastuzumab, pertuzumab) and tyrosine kinase inhibitors (tucatinib).
  • Recent advancements include antibody drug conjugates (ADCs) like trastuzumab-deruxtecan.
  • Neoadjuvant chemotherapy with trastuzumab is standard for localized disease, with T-DM1 used in adjuvant settings based on response.

Impact:

  • Significant improvement in the prognosis for HER2-positive breast cancer patients.
  • Personalized treatment strategies based on therapeutic response in localized disease.
  • Enhanced management for both metastatic and localized stages of HER2+ breast cancer.
Keywords:
Breast Neoplasms

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