Effect of transdermal azatadine on reducing histamine-induced wheal area

The effects of two strengths of azatadine maleate transdermal drug delivery system (TDDS) on histamine-induced wheal area were compared to standard oral doses of azatadine and placebo in 20 healthy male subjects. The two TDDSs and oral azatadine were equally effective compared with placebo (P = .0001) in reducing histamine-induced wheal area.