Inflammation and aging: signaling pathways and intervention therapies
Xia Li1,2,3,4, Chentao Li2,5, Wanying Zhang5
1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Signal Transduction and Targeted Therapy
|June 8, 2023
Summary
Inflammation drives aging by causing cellular senescence and organ dysfunction. Targeting this chronic inflammation, known as inflammaging, offers a promising strategy for anti-aging interventions and disease prevention.
Area of Science:
- Gerontology and Immunology
- Molecular and Cellular Biology
- Biomedical Sciences
Background:
- Aging is characterized by systemic chronic inflammation (inflammaging), cellular senescence, and immunosenescence.
- The senescence-associated secretory phenotype (SASP) from senescent cells exacerbates inflammation and induces further senescence.
- Chronic inflammation accelerates immune cell aging, creating a detrimental cycle that impairs tissue function and promotes age-related diseases.
Purpose of the Study:
- To systematically organize the complex phenomenon of inflammaging across molecular, cellular, and organ levels.
- To review current aging models and the impact of single-cell technologies on understanding aging.
- To highlight potential anti-aging strategies focused on mitigating inflammation.
Main Methods:
- Literature review of inflammaging mechanisms, aging models, and single-cell technologies.
- Analysis of the interplay between cellular senescence, immune function, and organ health.
- Discussion of potential therapeutic interventions targeting inflammation in aging.
Main Results:
- Inflammaging is a key driver of aging, linked to organ dysfunction and age-related diseases.
- A vicious cycle exists between chronic inflammation and cellular senescence, weakening immune responses.
- Persistent inflammation in organs like bone marrow, liver, and lungs contributes to damage and aging.
Conclusions:
- Inflammation is an endogenous aging factor, and its elimination is a potential anti-aging strategy.
- Understanding inflammaging provides a theoretical basis for developing novel anti-aging interventions.
- The ultimate goal is to prevent/alleviate age-related diseases and improve quality of life through targeted strategies.
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