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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
247
Cerebellar Microstructural Abnormalities in Obsessive-Compulsive Disorder (OCD): a Systematic Review of Diffusion
Parnian Shobeiri1,2,3, Sedighe Hosseini Shabanan4, Maryam Haghshomar5,6
1Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Parnian.Shobeiri@gmail.com.
Cerebellum (London, England)
|June 8, 2023
Summary
Obsessive-compulsive disorder (OCD) is linked to changes in cerebellar white matter integrity. Diffusion tensor imaging (DTI) studies reveal varied microstructural abnormalities, suggesting cerebellum
Area of Science:
- Neuroimaging
- Neuropsychiatry
- Brain Connectivity
Background:
- Obsessive-compulsive disorder (OCD) is increasingly linked to cerebellar dysfunction.
- Previous studies suggest altered resting-state functional connectivity involving the cerebellum in OCD patients.
Approach:
- A systematic review and meta-analysis of 17 diffusion tensor imaging (DTI) studies was conducted.
- PRISMA 2020 protocol guided the literature search and data synthesis.
- Fractional anisotropy (FA) and diffusivity metrics (MD, RD, AD) were analyzed to assess white matter integrity.
Key Points:
- Cerebellar white matter integrity shows variable changes in OCD, with conflicting reports on FA.
- Increased diffusivity parameters (MD, RD, AD) in the cerebellum were reported in four studies.
- Altered cerebellar connectivity with other brain regions was detected in three studies.
Conclusions:
- OCD is associated with widespread cerebellar white matter abnormalities and altered connectivity.
- DTI data from the cerebellum may aid in OCD diagnosis and prognosis prediction.
- Machine learning models could leverage cerebellar DTI features for clinical applications.
