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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Published on: August 23, 2024
Administration of Inhibitory Molecules through Nanoparticles in Breast Cancer Therapy
Christian Rafael Quijia1, Andreina Quevedo Enríquez2, Carlos Daniel Zappia2
1Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01 - s/n - Campos Ville, 14800-903 Araraquara, Sao Paulo, Brazil.
Abstract:
According to Global Cancer Statistics, breast cancer is the second leading cause of mortality in women. While there are several treatments for breast cancer, they are not always effective. In most cases, after initial treatment, patients may present a low response to therapy, more severe relapses, and even drug resistance. Hence, more effective and targeted therapies are needed. Recently, the use of nanoparticles has emerged as a promising alternative that will allow the controlled release of drugs in response to stimuli, precise delivery to the site of action, lower levels of toxicity, and fewer side effects. In this review, we provide an overview of the recent evidence proposing the delivery of inhibitory molecules encapsulated in nanoparticles as a new therapy for breast cancer that targets the signaling pathways governing the processes of tumor formation, maintenance, and expansion.
Insights
New nanoparticle therapies offer targeted breast cancer treatment. Encapsulating inhibitory molecules in nanoparticles improves drug delivery, reducing side effects and overcoming drug resistance for better patient outcomes.
Area of Science:
- Oncology and Nanomedicine
- Molecular Biology and Cancer Signaling
Background:
- Breast cancer remains a significant global health challenge, ranking as the second leading cause of mortality in women.
- Current breast cancer treatments often face limitations, including low therapeutic response rates, severe relapses, and the development of drug resistance.
- There is a critical need for innovative and more effective therapeutic strategies to improve patient survival and quality of life.
Approach:
- This review explores the potential of nanoparticles for targeted drug delivery in breast cancer therapy.
- Nanoparticles enable controlled release of therapeutic agents in response to specific stimuli.
- The precise delivery of inhibitory molecules via nanoparticles aims to minimize toxicity and reduce side effects.
Key Points:
- Nanoparticle-based drug delivery systems offer enhanced therapeutic efficacy for breast cancer.
- Targeting specific signaling pathways involved in tumor growth and progression is a key strategy.
- This approach holds promise for overcoming limitations associated with conventional breast cancer treatments.
Conclusions:
- The encapsulation of inhibitory molecules within nanoparticles represents a promising novel therapeutic avenue for breast cancer.
- This strategy facilitates targeted intervention in tumor formation, maintenance, and expansion processes.
- Nanoparticle-mediated drug delivery shows potential for improved treatment outcomes and reduced adverse effects in breast cancer patients.
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