[Influence of rs2587552 polymorphism of

Area of Science:

• Genetics
• Pediatrics
• Public Health

Background:

• Childhood obesity is a growing public health concern with complex etiologies.
• Genetic factors play a role in obesity susceptibility and intervention response.
• The DRD2 gene, particularly the rs1800497 polymorphism, has been linked to obesity, with rs2587552 in strong linkage disequilibrium.

Purpose of the Study:

• To investigate the association between the DRD2 gene rs2587552 polymorphism and the effectiveness of a childhood obesity intervention in a Chinese population.
• To explore the potential for personalized obesity interventions based on genetic profiles.

Main Methods:

• A multi-center cluster randomized controlled trial involving 382 children (intervention and control groups) in Beijing.
• DNA extraction from saliva samples to genotype the DRD2 rs2587552 polymorphism.
• Analysis of interactions between the gene polymorphism and intervention arms on various childhood obesity indicators.

Main Results:

• No association between rs2587552 and changes in hip circumference or body fat percentage in the intervention group.
• In the control group, the A allele was associated with increased hip circumference and body fat percentage.
• Significant interactions between rs2587552 and intervention arms were observed for hip circumference and body fat percentage.
• Children with the A allele in the intervention group showed decreased hip circumference and body fat percentage compared to controls without the A allele.

Conclusions:

• The A allele of DRD2 rs2587552 polymorphism may indicate a higher sensitivity to obesity interventions.
• Personalized childhood obesity lifestyle interventions could potentially be tailored based on the rs2587552 genotype.
• This finding provides a genetic basis for future individualized approaches to managing childhood obesity.