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Powder mixing in direct compression formulation by ordered and random processes.

M C Johnson

    The Journal of Pharmacy and Pharmacology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Researchers studied the mixing of cohesive tetracycline with spray-dried lactose (SDL). Mixture quality significantly improved using crystalline lactose (CL) or finer SDL particles, attributed to reduced segregation.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science
    • Chemical Engineering

    Background:

    • Understanding powder mixing is crucial for direct compression tablet manufacturing.
    • Cohesive drug-vehicle interactions can impact blend uniformity.
    • Spray-dried lactose (SDL) is a common direct compression vehicle.

    Purpose of the Study:

    • To investigate the mixing behavior of cohesive tetracycline with spray-dried lactose (SDL).
    • To evaluate the impact of lactose particle size and type on mixture quality.
    • To identify the mechanisms responsible for poor mixing in certain formulations.

    Main Methods:

    • Powder samples analyzed using chemical analysis.
    • Mixture homogeneity assessed via fluorescence microscopy.

    Related Experiment Videos

  • Coefficient of variation (Cv) used to quantify mixture quality.
  • Fractionation of spray-dried lactose (SDL) by particle size.

    • Main Results:

    • Both random and ordered mixing occurred at 0.25% w/w tetracycline concentration.
    • Mixture quality was superior with crystalline lactose (CL) (Cv=1%) compared to SDL (Cv=4%).
    • Finer SDL particles (<106 micron) yielded better mixture quality (Cv=2%) than coarser particles (106-300 micron, Cv=12%).

    Conclusions:

    • Ordered unit segregation negatively impacts mixture quality with spray-dried lactose (SDL).
    • Particle size control of SDL is critical for achieving uniform powder blends.
    • Crystalline lactose (CL) offers superior mixing performance for cohesive drug formulations.