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Updated: Jul 27, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA
Laura Tebcharani1, Nahida Akter2, Di Fan3,4
1Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, Garching 85748, Germany. job.boekhoven@tum.de.
Abstract:
Several challenges need to be overcome when applying nucleic acids as therapeutic agents. We developed a new way to control the onset of the release of cholesterol-conjugated oligonucleotides with a simple, versatile, and cheap platform. Moreover, we combine the platform into a dual-release system that can release a hydrophobic drug with zero-order kinetics, followed by a rapid release of cholesterol-conjugated DNA.
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