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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
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Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas
Nicholas S Cho1,2,3,4, Francesco Sanvito1,2, Shruti Thakuria1,2
1UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, USA.
Journal of Neuro-Oncology
|June 9, 2023
Summary
Sodium MRI measurements correlate positively with proton diffusion MRI in gliomas, suggesting extracellular water. This finding may help understand brain tumor microenvironments using multinuclear MRI contrast.
Area of Science:
- Neuroimaging
- Oncology
- Biophysics
Background:
- Limited understanding of sodium and proton MRI associations in brain tumors.
- Need for quantitative analysis of sodium, diffusion, and perfusion MRI in gliomas.
Purpose of the Study:
- To quantify intra- and intertumoral correlations between sodium, diffusion (ADC), and perfusion (nrCBV) MRI in human gliomas.
- To investigate the relationship between these MRI metrics across different tumor subregions.
Main Methods:
- Prospective study of 20 glioma patients using 3T MRI with multinuclear capabilities.
- Segmentation of three tumor volumes of interest: contrast-enhancing tumor (CET), non-enhancing tumor (NET), and necrosis.
- Quantification of median and voxel-wise associations between ADC, nrCBV, and sodium measurements within each VOI.
Main Results:
- Sodium concentration and ADC were significantly higher in necrosis compared to NET and CET.
- Sodium concentration was higher in CET than NET.
- Positive correlations found between sodium and ADC in NET and CET (r=0.77-0.84).
- Negative correlation observed between sodium and nrCBV in NET (r=-0.63).
Conclusions:
- Sodium MRI is positively correlated with proton diffusion MRI (ADC) in gliomas, likely indicating extracellular water.
- Multinuclear MRI contrast offers potential for future studies on tumor microenvironment chemistry.
