Related Experiment Video
Updated: Jul 27, 2025
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
2.8K
Opportunistic screening for asymptomatic left ventricular dysfunction in type 2 diabetes mellitus
Mi Zhou1, Duo Huang1, Yangyang Cheng1
1Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Postgraduate Medical Journal
|June 9, 2023
Summary
Screening for heart failure using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in type 2 diabetes patients is feasible. This approach aids in the early detection of cardiovascular complications, improving patient outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Biomarker Research
Background:
- International guidelines advocate natriuretic peptide biomarker screening for early heart failure (HF) detection in high-risk individuals.
- Limited data exists on integrating such screening into routine clinical practice.
Purpose of the Study:
- To implement a screening program for left ventricular dysfunction in patients diagnosed with type 2 diabetes mellitus (DM).
Main Methods:
- A prospective screening study was conducted at a dedicated DM complication screening center.
- Recruited 1043 patients with type 2 diabetes between 2018 and 2019.
- Assessed N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels and performed electrocardiograms (ECG).
Main Results:
- 4.1% of patients had elevated NT-proBNP levels, indicating potential HF.
- 4.1% of patients were newly diagnosed with atrial fibrillation (AF).
- Elevated NT-proBNP prevalence increased with age and worsening kidney function; male gender, prior stroke, CKD, and new AF were associated with higher NT-proBNP.
Conclusions:
- NT-proBNP and ECG screening are easily implementable in type 2 diabetes patients.
- This screening facilitates early detection of cardiovascular complications.
- Early detection can lead to improved long-term patient outcomes.
Related Concept Videos
01:15Diabetes: Symptoms, Diagnosis, and Complications
605
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
605
01:22Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
01:22Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
26
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
26
01:30Dysrhythmias V: Evaluating Dysrhythmias
42
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
42
01:30Heart Failure IV: Classification and Diagnostic Evaluation
21
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
21