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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

408
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
408
Drug Delivery: Overview01:16

Drug Delivery: Overview

329
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
329
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

526
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
526
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

645
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
645
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.8K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Related Experiment Video

Updated: Jul 27, 2025

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
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Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

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Solid implantable devices for sustained drug delivery.

Elizabeth Magill1, Sara Demartis2, Elisabetta Gavini3

  • 1School of Pharmacy, Queen's University Belfast, 97, Lisburn Road, Belfast BT9 7BL, UK.

Advanced Drug Delivery Reviews
|June 9, 2023
PubMed
Summary
This summary is machine-generated.

Implantable drug delivery systems (IDDS) offer sustained drug release, overcoming limitations of oral and injectable methods. They are ideal for chronic conditions, enabling localized or systemic delivery to improve patient adherence and therapeutic outcomes.

Keywords:
Biodegradable polymersImplantLocal drug deliverySustained drug release

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Technologies
  • Pharmacology

Background:

  • Conventional drug administration (oral, injectable) leads to fluctuating blood concentrations, requiring frequent dosing.
  • Challenges with oral delivery include gastrointestinal degradation and first-pass metabolism.
  • Implantable drug delivery systems (IDDS) offer a solution for sustained and controlled drug release.

Purpose of the Study:

  • To review current applications of implantable drug delivery systems (IDDS).
  • To focus on the materials utilized in the fabrication of IDDS.
  • To highlight the primary therapeutic areas where IDDS are applied.

Main Methods:

  • Literature review of existing research on IDDS.
  • Analysis of materials used in IDDS development.
  • Categorization of IDDS applications by therapeutic area.

Main Results:

  • IDDS provide prolonged drug delivery, enhancing therapeutic efficacy.
  • Materials for IDDS range from polymers to metals, tailored for specific release profiles.
  • Key applications include chronic disease management, pain control, and localized cancer therapy.

Conclusions:

  • IDDS represent a significant advancement over conventional drug delivery methods.
  • Material selection is critical for optimizing IDDS performance and safety.
  • IDDS offer improved patient compliance and targeted drug delivery, particularly for chronic conditions.