Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lateralization01:28

Lateralization

375
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
375
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

764
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
764
Cerebral Hemispheres01:05

Cerebral Hemispheres

405
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
405
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

939
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
939
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

590
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
590
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.6K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excessive Censoring Degrades Individual-Specific Cortical Parcellations and Personalized TMS Targets.

bioRxiv : the preprint server for biology·2026
Same author

Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.

Molecular psychiatry·2026
Same author

Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.

bioRxiv : the preprint server for biology·2026
Same author

Precision Functional Parcellation of the Human Cortex via Rest-Task fMRI Fusion.

bioRxiv : the preprint server for biology·2026
Same author

Association of Genetic Liability to Psychiatric Disorders with Peripheral Metabolic Dysregulation.

medRxiv : the preprint server for health sciences·2026
Same author

Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jul 27, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Language network lateralization is reflected throughout the macroscale functional organization of cortex.

Loïc Labache1, Tian Ge2,3,4, B T Thomas Yeo5,6,7,8,9

  • 1Department of Psychology, Yale University, New Haven, CT, 06520, US. loic.labache@yale.edu.

Nature Communications
|June 9, 2023
PubMed
Summary

Atypical language dominance in humans is linked to widespread changes in brain organization, with genetic factors influencing both language lateralization and these broader cortical patterns.

More Related Videos

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 27, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K

Area of Science:

  • Neuroscience
  • Human Brain Organization
  • Cognitive Neuroscience

Background:

  • Hemispheric specialization is key to brain function, but its extent across cortical architecture is debated.
  • Most individuals show left-hemisphere dominance for language, yet a significant minority exhibits reverse lateralization.

Purpose of the Study:

  • To investigate the relationship between atypical language dominance and global cortical organization.
  • To explore the genetic underpinnings of language lateralization and cortical asymmetries.

Main Methods:

  • Utilized twin and family data from the Human Connectome Project.
  • Analyzed macroscale functional gradients across the cortex.
  • Examined hemispheric differences in cortical organization related to language dominance.

Main Results:

  • Atypical language dominance correlates with global shifts in cortical functional organization.
  • Hemispheric differences in functional gradients are observed in individuals with atypical language organization.
  • Both language lateralization and gradient asymmetries show partial genetic influence.

Conclusions:

  • Atypical language dominance is associated with distinct patterns of global cortical organization.
  • Genetic factors play a role in both language lateralization and macroscale cortical asymmetries.
  • Findings enhance understanding of variability in hemispheric specialization and cortical architecture.