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Tu Cam Nguyen1,2, Ngoc Le Chau Tang3, Giao Kim Ngoc Le4

  • 1Department of Gastroenterology, City Children's Hospital, Ho Chi Minh City 700000, Vietnam.

Healthcare (Basel, Switzerland)
|June 10, 2023
PubMed
Summary

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Helicobacter pylori (H. pylori) infection is highly prevalent in Vietnamese children, with 80% testing positive. This high rate correlates with a significant burden of peptic ulcers, emphasizing the need for early detection programs.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Public Health

Background:

  • Helicobacter pylori (H. pylori) is a significant cause of gastroduodenal diseases globally.
  • Understanding the infection burden in pediatric populations is crucial for disease prevention and management.

Purpose of the Study:

  • To assess the prevalence of H. pylori infection in symptomatic Vietnamese children.
  • To determine the association between H. pylori infection and peptic ulcer disease in this demographic.

Main Methods:

  • A cohort of 336 children (aged 4-16) undergoing esophagogastroduodenoscopy in Ho Chi Minh City were enrolled.
  • H. pylori infection was diagnosed using a combination of culture, histopathology, rapid urease test, and PCR for the urease gene.
  • Exclusion criteria included recent use of proton pump inhibitors or antibiotics, and prior endoscopic procedures.
Keywords:
Helicobacter pyloribiopsy-based testspeptic ulcer diseasesymptomatic childrenvirulence factors

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Main Results:

  • H. pylori infection was detected in 80% of the enrolled children.
  • Peptic ulcers were present in 19% of the children, with prevalence increasing with age.
  • The cagA+ H. pylori strain was more frequently found in children with peptic ulcers.

Conclusions:

  • Symptomatic Vietnamese children exhibit a high prevalence of H. pylori infection and associated peptic ulcers.
  • Implementing early H. pylori detection programs is vital to mitigate ulcer risks and potentially prevent gastric cancer in the long term.