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In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine

Arunachalam Muthuraman1, Muthusamy Ramesh2, Fazlina Mustaffa1

  • 1Pharmacology Unit, Faculty of Pharmacy, AIMST University, Bedong 08100, Malaysia.

Molecules (Basel, Switzerland)
|June 10, 2023
PubMed

Keywords:
Alzheimer’s diseaseacid phosphatasegalatamineneurovascular disordersrivastigminevascular dementiazebrafish embryo toxicity test

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Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
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