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Colloids03:22

Colloids

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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Solution, Solubility, and Solubility Equilibrium
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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Polymer Classification: Stereospecificity01:26

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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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Structural Behavior of Amphiphilic Triblock Copolymer P104/Water System.

Edgar Benjamín Figueroa-Ochoa1, Lourdes Mónica Bravo-Anaya2,3,4, Ricardo Vaca-López1

  • 1Departamento de Química, Universidad de Guadalajara, Blvd. M. García Barragán #1451, Guadalajara 44430, Jalisco, Mexico.

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|June 10, 2023
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Summary

This study details the structural transitions of Pluronic P104 triblock copolymer in water across various temperatures and concentrations. Findings reveal distinct regions of monomer existence, micelle formation, and liquid crystalline behavior, aiding drug delivery applications.

Keywords:
P104phase diagramrheological behaviorspherical and elongated micelles

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Area of Science:

  • Polymer Science
  • Materials Science
  • Physical Chemistry

Background:

  • Triblock copolymers like PEO-PPO-PEO are crucial in various applications, including drug delivery.
  • Understanding their phase behavior in aqueous solutions is essential for optimizing their use.
  • Pluronic P104 (PEO27-PPO61-PEO27) exhibits complex self-assembly in water.

Purpose of the Study:

  • To investigate the structural transitions of Pluronic P104 in water.
  • To map the phase behavior as a function of temperature and copolymer concentration.
  • To provide a phase diagram for potential applications in drug delivery.

Main Methods:

  • Utilized a combination of complementary techniques: viscosimetry, densimetry, dynamic light scattering, turbidimetry, polarized microscopy, and rheometry.
  • Calculated hydration profiles using density and sound velocity measurements.
  • Explored concentrations from 1 × 10-4 to 90 wt.% and temperatures from 20 to 75 °C.

Main Results:

  • Identified distinct regions corresponding to monomeric state, spherical micelle formation, and elongated cylindrical micelle formation.
  • Determined clouding points and observed liquid crystalline behavior at higher concentrations and temperatures.
  • Generated a partial phase diagram illustrating these transitions.

Conclusions:

  • The study provides a comprehensive understanding of Pluronic P104 aqueous solution behavior.
  • The phase diagram is valuable for designing formulations for drug delivery systems.
  • The identified structural transitions are critical for controlling copolymer self-assembly and interactions with active principles.