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Related Experiment Video

Updated: Jul 27, 2025

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
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Lateral Filter Array Microfluidic Devices for Detecting Circulating Tumor Cells.

Kangfu Chen1, Thomas J George2, Z Hugh Fan3,4,5

  • 1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|June 10, 2023
PubMed
Summary
This summary is machine-generated.

Circulating tumor cells (CTCs) are crucial liquid biopsy biomarkers, but their rarity poses challenges. This study introduces a novel lateral filter array microfluidic (LFAM) device for highly efficient CTC isolation and enumeration from blood samples.

Keywords:
Circulating tumor cellsFiltrationImmunoaffinityMicrofluidicsPancreatic cancer

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Microfluidics

Background:

  • Circulating tumor cells (CTCs) are vital biomarkers for cancer diagnosis and prognosis.
  • The clinical application of CTCs is limited by their extremely low abundance in peripheral blood.

Purpose of the Study:

  • To develop and detail the design and fabrication of a lateral filter array microfluidic (LFAM) device.
  • To demonstrate the application of LFAM devices for efficient isolation and enumeration of CTCs from clinical blood samples.

Main Methods:

  • Development of a novel lateral filter array microfluidic (LFAM) device.
  • Detailed description of the LFAM device's design and fabrication process.
  • Application of the LFAM device for CTC isolation and enumeration in clinical samples.

Main Results:

  • The LFAM device enables highly efficient isolation of circulating tumor cells.
  • The developed microfluidic technology facilitates accurate CTC enumeration from patient blood.

Conclusions:

  • Lateral filter array microfluidic (LFAM) devices offer a promising solution for overcoming the challenges of CTC detection.
  • This technology enhances the clinical utility of CTCs as liquid biopsy biomarkers for cancer management.