Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.8K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Phases of Wound Repair01:28

Phases of Wound Repair

6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same author

The periderm in mouse skin development: Evidence for conservation across mammalian species.

The Journal of investigative dermatology·2026
Same author

Electroactive microneedle augmented stem cell therapy in myocardial infarction.

Science advances·2026
Same author

Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration.

Nature biomedical engineering·2026
Same author

Self-Assembly of Human Embryonic-Stem-Cell-Derived Keratinocytes and Fibroblasts into 3D Spheroid Structures for Epidermal Regeneration In Vivo.

Cells·2026
Same author

Network pharmacology-guided self-assembling quercetin hydrogel from Astragalus membranaceous accelerates diabetic wound healing.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same journal

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice.

Nature communications·2026
Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026
Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026
Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026
Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026
Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.3K

Scarless wound healing programmed by core-shell microneedles.

Ying Zhang1, Shenqiang Wang2, Yinxian Yang1

  • 1Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.

Nature Communications
|June 10, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microneedle patch that dynamically adjusts wound healing. The programmed microneedles (PF-MNs) combat bacteria, reduce inflammation, and prevent scarring for improved tissue repair.

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.2K

Related Experiment Videos

Last Updated: Jul 27, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.3K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.2K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Chronic wound healing is complex, often failing due to drug delivery challenges and improper timing.
  • Existing treatments struggle to address the dynamic microenvironment of healing wounds effectively.

Purpose of the Study:

  • To develop a programmable microneedle array patch (PF-MNs) for dynamic modulation of the wound immune microenvironment.
  • To address limitations in drug delivery efficacy and therapeutic timing during distinct wound healing phases.

Main Methods:

  • Designed a core-shell microneedle array patch with programmed functions (PF-MNs).
  • Utilized laser-induced reactive oxygen species (ROS) for early-stage bacterial biofilm disruption.
  • Incorporated a ROS-sensitive shell for controlled release of anti-inflammatory and anti-scarring agents (verteporfin).

Main Results:

  • PF-MNs demonstrated effective combatting of multidrug-resistant bacterial biofilms via ROS generation.
  • The microneedle core successfully neutralized inflammatory factors, promoting transition from inflammation to proliferation.
  • Verteporfin release inhibited scar formation by blocking Engrailed-1 (En1) activation in fibroblasts.
  • PF-MNs promoted scarless repair in acute and chronic mouse wound models and reduced hypertrophic scarring in rabbit ears.

Conclusions:

  • The developed PF-MNs offer a promising strategy for dynamic, phase-specific wound management.
  • This technology effectively addresses bacterial infection, inflammation, and scar formation in wound healing.
  • PF-MNs represent a significant advancement in regenerative medicine for improved wound repair outcomes.