Reduction of SPECT acquisition time using deep learning: A phantom study

Single photon emission computed tomography (SPECT) procedures are characterized by long acquisition time to acquire diagnostically acceptable image data. The goal of this investigation was to assess the feasibility of using a deep convolutional neural network (DCNN) to reduce the acquisition time. The DCNN was implemented using the PyTorch and trained using image data from standard SPECT quality phantoms. The under-sampled image dataset is provided to neural network as input, while missing projections were provided as targets. The network is to produce for the output the missing projections. The baseline method of calculating the missing projections as arithmetic means of adjacent ones was introduced. The obtained synthesized projections and reconstructed images were compared to original data and baseline data across several parameters using PyTorch and PyTorch Image Quality code libraries. Results obtained from comparisons of projection and reconstructed image data show the DCNN clearly outperforming the baseline method. However, subsequent analysis revealed the synthesized image data being more comparable to under-sampled than to fully-sampled image data. The results of this investigation imply that neural network can replicate coarser objects better. However, densely sampled clinical image datasets, coarse reconstruction matrices and patient data featuring coarse structures combined with a lack of baseline data generation methods will hamper the ability to analyse the neural network outputs correctly. This study calls for use of phantom image data and introduction of a baseline method in the evaluation of neural network outputs.