Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic effects of nicotine and hyperlipidemia induce cardiac damage via dynamic cardiomyocyte-based biosensing.

Microsystems & nanoengineering·2026
Same author

Integrated precise temperature regulation and electrophysiology sensing system for nanoplasmonic photothermal cardiac bradyarrhythmia therapy.

Microsystems & nanoengineering·2026
Same author

High encoding-sensitivity vision sensor with complementary nonlinear neuromorphic computing.

Nature communications·2026
Same author

Scalable Nanoedge Interfaces for Robust Intracellular Electrophysiology in Cardiomyocytes.

Nano letters·2026
Same author

Conformationally Regulated CRISPR/Cas12a Activation Enabled by a Programmable DNA Dumbbell for Electrochemical SNP Genotyping.

Analytical chemistry·2026
Same author

Low-dimensional materials for intracellular electrophysiology: advances from synthesis to applications.

Microsystems & nanoengineering·2026

Related Experiment Video

Updated: Jul 27, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.6K

Three-Dimensional Cardiomyocyte-Nanobiosensing System for Specific Recognition of Drug Subgroups.

Kai Zhu1, Tao Yan1, Chunlian Qin2

  • 1Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai 200032, China.

ACS Sensors
|June 12, 2023
PubMed
Summary

A new biosensing system uses nanopillars to record high-quality cardiac cell electrical activity. This platform accurately distinguishes drug effects, aiding cardiovascular disease research and drug screening.

Keywords:
cardiomyocytecardiomyocyte−nanobiosensing systemenhanced recognitionintracellular electrophysiologyion channel blocker

More Related Videos

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

1.8K
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
10:39

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Published on: April 15, 2017

12.9K

Related Experiment Videos

Last Updated: Jul 27, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.6K
Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

1.8K
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
10:39

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Published on: April 15, 2017

12.9K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Nanotechnology

Background:

  • Cardiovascular diseases are linked to abnormal cardiac electrophysiology.
  • Accurate drug screening platforms are essential for cardiovascular research.
  • Conventional extracellular recordings provide limited, low-quality data for drug screening.

Purpose of the Study:

  • To develop a novel 3D cardiomyocyte-nanobiosensing system for drug subgroup recognition.
  • To improve the accuracy and sensitivity of electrophysiological monitoring in cardiomyocytes.
  • To establish a platform for high-content intracellular recordings for pharmacological investigation.

Main Methods:

  • Fabrication of a nanopillar-based electrode using template synthesis and microfabrication.
  • Development of a cardiomyocyte-nanopillar interface on a porous membrane.
  • Minimally invasive electroporation for high-quality intracellular action potential recording.
  • Validation using sodium channel blockers quinidine and lidocaine.

Main Results:

  • The developed system successfully recorded high-quality intracellular action potentials.
  • The platform accurately differentiated between subclasses of sodium channel blockers.
  • Subtle differences in drug effects were revealed by the recorded data.

Conclusions:

  • The nanopillar-based biosensing platform offers a promising approach for electrophysiological and pharmacological studies.
  • This system enables high-content intracellular recordings for cardiovascular disease research.
  • The technology facilitates accurate drug screening and subgroup recognition.