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Updated: Jul 26, 2025

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Pain Management during Ultrasound Guided Transvaginal Oocyte Retrieval - A Narrative Review
Puvithra Thanikachalam1, Dilip Kumar Govindan2
1Department of Obstetrics and Gynaecology, Chettinad Fertility Services, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Journal of Human Reproductive Sciences
|June 12, 2023
Summary
Conscious sedation is the preferred anesthesia for transvaginal oocyte retrieval (TVOR) due to fewer side effects and better outcomes. Combining it with a paracervical block may further improve oocyte quality.
Area of Science:
- Reproductive Medicine
- Anesthesiology
- In Vitro Fertilization
Background:
- Transvaginal oocyte retrieval (TVOR) for assisted reproduction can cause significant pain, necessitating effective analgesia.
- Anesthetic choices for TVOR must consider potential impacts on oocyte quality and embryo development.
Purpose of the Study:
- To review anesthesia methods and drugs for safe and effective pain management during TVOR.
- To evaluate anesthetic effects on oocyte quality and patient outcomes.
Main Methods:
- Systematic review of Medline, Embase, PubMed, and Cochrane databases.
- Adherence to modified Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines.
Main Results:
- Conscious sedation is favored for TVOR, offering reduced adverse effects, quicker recovery, and improved comfort for patients and specialists.
- Conscious sedation demonstrates minimal impact on oocyte quality and embryo development.
- Combining conscious sedation with a paracervical block decreased anesthetic drug consumption, potentially benefiting oocyte quality.
Conclusions:
- Conscious sedation is the optimal anesthesia choice for TVOR, balancing efficacy, safety, and reproductive outcomes.
- Paracervical block in conjunction with conscious sedation may enhance oocyte quality by reducing anesthetic requirements.

