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Updated: Jul 26, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Synthesis of α-allenic aldehydes/ketones from homopropargylic alcohols using a visible-light irradiation system
Dong-Fang Jiang1,2, Xing-Xing Zeng1, De-Feng Li3
1Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Provincial first-class applied discipline (pharmacy), Changsha, 410000, China. dg1824035@smail.nju.edu.cn.
Abstract:
A visible-light irradiation tandem oxidative aryl migration/carbonyl formation reaction, mediated by K2S2O8 and visible-light photoredox catalysis, has been discovered. The presented transformation provides a straightforward access to important α-allenic aldehyde/ketone derivatives from readily available homopropargylic alcohol derivatives in a regioselective manner of 1,4-aryl shift concomitant with carbonyl formation. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional α-allenic aldehyde/ketone derivatives.
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