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Related Experiment Video

Updated: Jul 26, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

New prediction categories in CASP15.

Andriy Kryshtafovych¹, Maciej Antczak^2,3, Marta Szachniuk^2,3

¹Genome Center, University of California, Davis, California, USA.

|June 12, 2023

Summary

The Critical Assessment of Structure Prediction (CASP) introduced new categories in CASP15 for RNA structure, ligand-protein complexes, oligomeric accuracy, and conformational ensembles. These updates address evolving challenges in protein structure modeling.

Keywords:

3D structure prediction CASP15 RNA structure protein structure protein-ligand complexes

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Last Updated: Jul 26, 2025

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Published on: January 26, 2024

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Published on: July 21, 2022

Area of Science:

Computational biology
Structural biology
Bioinformatics

Background:

The Critical Assessment of Structure Prediction (CASP) evolves to meet new challenges in structure modeling.
CASP experiments drive advancements in protein structure prediction accuracy.

Purpose of the Study:

To detail the technical specifications for four new prediction categories introduced in CASP15.
To describe the integration of these new categories into the CASP data management system.

Main Methods:

Listing technical specifications for new CASP15 categories.
Describing the integration process within the CASP data management system.

Main Results:

Four new prediction categories were established for CASP15: RNA structure, ligand-protein complexes, accuracy of oligomeric structures and their interfaces, and ensembles of alternative conformations.
Technical specifications and data management integration plans for these categories have been defined.

Conclusions:

The introduction of new CASP categories reflects the need to address emerging problems in structure prediction.
These updates ensure CASP remains relevant in advancing the field of structural biology.