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Evolution of the newest diagnostic methods for COVID-19: a Chinese perspective
Mingtao Liu1, Jiali Lyu2, Xianhui Zheng1
1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China.
Insights
Accurate diagnosis of Coronavirus disease 2019 (COVID-19) is crucial for patient care and epidemic control. This review explores diverse diagnostic methods beyond RT-PCR, including AI and imaging, used in China.
Area of Science:
- Medical Diagnostics
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) rapidly spread globally, challenging healthcare systems.
- Accurate and timely diagnosis is essential for patient management, epidemic assessment, and control measures.
- Traditional methods like Reverse Transcription-Polymerase Chain Reaction (RT-PCR) have limitations.
Approach:
- This review examines various COVID-19 diagnostic methods applied in clinical practice in China.
- It includes molecular, immunodiagnostic, imaging, and artificial intelligence approaches.
- The focus is on methods that address diverse clinical scenarios and needs.
Key Points:
- Multiple diagnostic strategies exist for COVID-19, catering to different clinical requirements.
- Beyond RT-PCR, innovative methods like AI and advanced imaging offer complementary diagnostic capabilities.
- The integration of these diverse methods aids clinicians in diagnosing and treating COVID-19 patients effectively.
Conclusions:
- A comprehensive understanding of available diagnostic tools is vital for effective COVID-19 management.
- The reviewed methods provide a valuable reference for the clinical diagnosis of COVID-19, particularly highlighting Chinese advancements.
- Continued development and application of diverse diagnostic technologies are key to combating infectious disease outbreaks.
Abstract:
Coronavirus disease 2019 (COVID-19) has continued to spread globally since late 2019, representing a formidable challenge to the world's healthcare systems, wreaking havoc, and spreading rapidly through human contact. With fever, fatigue, and a persistent dry cough being the hallmark symptoms, this disease threatened to destabilize the delicate balance of our global community. Rapid and accurate diagnosis of COVID-19 is a prerequisite for understanding the number of confirmed cases in the world or a region, and an important factor in epidemic assessment and the development of control measures. It also plays a crucial role in ensuring that patients receive the appropriate medical treatment, leading to optimal patient care. Reverse transcription-polymerase chain reaction (RT-PCR) technology is currently the most mature method for detecting viral nucleic acids, but it has many drawbacks. Meanwhile, a variety of COVID-19 detection methods, including molecular biological diagnostic, immunodiagnostic, imaging, and artificial intelligence methods have been developed and applied in clinical practice to meet diverse scenarios and needs. These methods can help clinicians diagnose and treat COVID-19 patients. This review describes the variety of such methods used in China, providing an important reference in the field of the clinical diagnosis of COVID-19.
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