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Clinical uses of epigenetics in cardiology and cardiothoracic surgery: an update

James F Heinl1, Ghazal Aghagoli, Frank W Sellke1

  • 1Department of Cardiothoracic Surgery, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA.

Epigenomics
|June 13, 2023
PubMed

Insights

Epigenetics offers new ways to prevent, diagnose, and treat cardiovascular diseases. Recent advancements show its potential in cardiology and cardiothoracic surgery.

Area of Science:

  • Cardiovascular epigenetics research.
  • Exploration of epigenetic mechanisms in heart disease.

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide.
  • Epigenetics, the study of heritable gene expression changes without altering DNA sequence, is emerging as a key player in CVDs.

Discussion:

  • Epigenetic modifications like DNA methylation and histone modifications influence cardiac gene expression.
  • These changes can be influenced by environmental factors and lifestyle, impacting CVD development.

Key Insights:

  • Recent advances highlight epigenetics' role in CVD prevention and diagnosis.
  • Specific epigenetic markers are being investigated for early detection and risk stratification.
  • Therapeutic interventions targeting epigenetic pathways show promise in preclinical models.

Outlook:

  • Further research into epigenetic mechanisms will refine CVD diagnosis and treatment.
  • Personalized medicine approaches incorporating epigenetic profiles may improve patient outcomes.
  • The integration of epigenetics into clinical practice holds significant potential for cardiovascular health.

Keywords:
cardiologycardiothoracic surgerycardiovascular diseaseepigeneticsepipharmacogenetics

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