Related Experiment Video
Updated: Jul 26, 2025

A Visual Assay to Monitor T6SS-mediated Bacterial Competition
Published on: March 20, 2013
Virulence-associated type III secretion systems in Gram-negative bacteria
Sara Vilela Pais1, Eunjin Kim1, Samuel Wagner1,2,3
1Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany.
Bacterial type III secretion systems (T3SS) are molecular machines that help bacteria infect host cells. This review covers the assembly, structure, and function of these critical virulence factors.
Area of Science:
- Microbiology
- Molecular Biology
- Cell Biology
Background:
- Type III secretion systems (T3SS) are essential virulence factors in many pathogenic bacteria.
- These systems facilitate the direct injection of bacterial effector proteins into host cells.
Approach:
- This review synthesizes recent advancements in understanding T3SS.
- It discusses the assembly, structure, and functional mechanisms of these complex molecular machines.
Key Points:
- T3SS form needle-like structures called injectisomes that breach bacterial and host cell membranes.
- Delivered effector proteins manipulate host cell functions to promote bacterial pathogenesis.
- Recent research has significantly expanded knowledge on T3SS assembly, structure, and function.
Conclusions:
- A comprehensive understanding of T3SS is crucial for developing novel anti-bacterial strategies.
- This review provides a detailed overview of the current state of T3SS research.
More Related Videos
08:36Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth
Published on: May 31, 2024
12:23Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
Published on: October 13, 2015
Related Concept Videos
Gram-negative Bacterial Protein Secretion Systems
Bacterial Translocation and Protein Secretion
Bacterial Signaling
Gene Regulation in Microbial Communities: Quorum Sensing
Receptor-mediated Endocytosis
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Global Regulatory Systems